Phenotypes Associated with This Genotype

Genotype
MGI:4365574

hm4

• Allelic Composition: Terc^tm1Rdp/Terc^tm1Rdp
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

decreased elongated spermatid number ( J:98586 )

♂ • at 8 months of age, second generation (G2) homozygotes exhibit fewer intact elongating spermatids containing extended telomeres than wild-type or heterozygous littermates

♂ • however, fertility is preserved, suggesting that alternative telomere extension activity is capable of partially complementing the telomerase defect

abnormal telomere length ( J:98586 )

♂ • elongated spermatids from second generation (G2) homozygotes display variable telomere length, with some displaying long telomeres, while others have short telomeres

reproductive system

decreased elongated spermatid number ( J:98586 )

♂ • at 8 months of age, second generation (G2) homozygotes exhibit fewer intact elongating spermatids containing extended telomeres than wild-type or heterozygous littermates

♂ • however, fertility is preserved, suggesting that alternative telomere extension activity is capable of partially complementing the telomerase defect