Phenotypes Associated with This Genotype

Genotype
MGI:4360543

• Allelic Composition: Grin2a^tm1Nak/Grin2a^tm1Nak; Grin2c^tm1Nak/Grin2c^tm1Nak
• Genetic Background: involves: 129S/SvEv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:66455 )

N • no gross anatomical changes in the brain; the organization of the cerebellum is unaltered and the size and density of the granule cells is similar in mutant and control mice

abnormal excitatory postsynaptic currents ( J:66455 )

• evoked ESPCs are absent in cerebellar granule cells in double mutant mice

abnormal miniature excitatory postsynaptic currents ( J:66455 )

• the amplitude of the slow component (characteristic of NMDA receptor activity) of spontaneous ESPCs in cerebellar granule cells is nearly absent in mutant mice compared to controls

behavior/neurological

behavior/neurological phenotype ( J:66455 )

N • mutant mice do not exhibit ataxia or tremors, and grip strength and righting reflex is similar to controls

impaired balance ( J:66455 )

• double mutant mice do not maintain balance and cannot stand or walk on a 6mm wide fixed bar while control mice can walk smoothly and stay on the bar

• on a 20mm fixed bar, mutant mice can can walk smoothly and stay on the bar, similar to controls

• on a rotating rod at 25 rpm, mutant mice fail to stay on the rod and do not improve performance with training

• at 10 and 20 rpm, mutant mice perform similar to controls

decreased vertical activity ( J:66455 )

• the amount of rearing activity is significantly reduced in mutant mice compared to controls

• there is no difference in horizontal locomotor activity compared to controls