Phenotypes Associated with This Genotype

Genotype
MGI:4358954

• Allelic Composition: Nr1h2^tm1Djm/Nr1h2^tm1Djm
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:81696 )

• mice succumb to infection of Listeria monocytogenes 2-3 days earlier than controls

pregnancy-related premature death ( J:120923 )

• occasionally mothers fail to expulse pups from uterine horns leading rarely to death

immune system

increased susceptibility to bacterial infection ( J:81696 )

• mice succumb to infection of Listeria monocytogenes 2-3 days earlier than controls

reproductive system

abnormal spermatogonia proliferation ( J:120913 )

♂ • proliferation of male germ cells is significantly decreased compared to controls

abnormal Sertoli cell morphology ( J:120913 )

♂ • Sertoli cells have vacuoles containing cholesterol esters

abnormal myometrium morphology ( J:120923 )

♀ • vacuoles filled with cholesterol esters are present within the myoctes

♀ • concentration of cholesterol esters are about 25-fold higher at 3 and 12 months of age

abnormal parturition ( J:120923 )

♀ • occasionally mothers fail to expulse pups from uterine horns leading to hind-limb paralysis and rarely to death

abnormal uterus physiology ( J:120923 )

♀ • myometrium muscle has lower amplitudes of contraction compared to controls in response to pharmacological levels of oxytocin

endocrine/exocrine glands

abnormal Sertoli cell morphology ( J:120913 )

♂ • Sertoli cells have vacuoles containing cholesterol esters

behavior/neurological

hindlimb paralysis ( J:120923 )

• occasionally mothers fail to expulse pups from uterine horns leading to hind-limb paralysis and rarely to death

muscle

impaired smooth muscle contractility ( J:120923 )

• myometrium (uterus) muscle has lower amplitudes of contraction compared to controls in response to pharmacological levels of oxytocin

cellular

abnormal spermatogonia proliferation ( J:120913 )

♂ • proliferation of male germ cells is significantly decreased compared to controls