Phenotypes Associated with This Genotype

Genotype
MGI:4358058

• Allelic Composition: Tsc2^tm2.2Djk/Tsc2⁺
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased renal cystadenoma incidence ( J:149326 )

• both gross and microscopic tumor scores were markedly reduced in the Tsc2^tm2.2Djk mice compared with the Tsc2^tm1Djk mice

• the percent cellularity of the lesions was also reduced in the Tsc2^tm2.2Djk mice compared with the Tsc2^tm1Djk mice

• qualitatively, the tumors from the Tsc2^tm2.2Djk mice were obviously smaller in size and growth appearance compared with the Tsc2^tm1Djk mice

• at age 18 months tumors from Tsc2^tm2.2Djk mice became comparable to those seen in the Tsc2^tm1Djk mice at age 12 months

renal/urinary system

increased renal cystadenoma incidence ( J:149326 )

• both gross and microscopic tumor scores were markedly reduced in the Tsc2^tm2.2Djk mice compared with the Tsc2^tm1Djk mice

• the percent cellularity of the lesions was also reduced in the Tsc2^tm2.2Djk mice compared with the Tsc2^tm1Djk mice

• qualitatively, the tumors from the Tsc2^tm2.2Djk mice were obviously smaller in size and growth appearance compared with the Tsc2^tm1Djk mice

• at age 18 months tumors from Tsc2^tm2.2Djk mice became comparable to those seen in the Tsc2^tm1Djk mice at age 12 months

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
tuberous sclerosis		DOID:13515	OMIM:PS191100	J:149326