Phenotypes Associated with This Genotype

Genotype
MGI:4357972

cn3

• Allelic Composition: Lat^tm1.1Mal/Lat^{tm6.1(HBEGF/EGFP)Mal}
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal T-helper 2 physiology ( J:151840 )

• CD4⁺ T cells were first transfected with a cre recombinase vector and then treated with dipthera toxin so that surviving T cells only expressed the mutant Lat^tm1Mal allele

• when activated and transferred into T cell deficient hosts, these T cells cause splenomegaly, lymphadenopathy and secrete high levels of IL-4

• these abnormal T cells promote B cell activation in their hosts leading to high levels of IgG1 and IgE

• T cells are not pathogenic when transferred into MHC-II deficient hosts or in the absence of CD28 signalling

hematopoietic system

abnormal T-helper 2 physiology ( J:151840 )

• CD4⁺ T cells were first transfected with a cre recombinase vector and then treated with dipthera toxin so that surviving T cells only expressed the mutant Lat^tm1Mal allele

• when activated and transferred into T cell deficient hosts, these T cells cause splenomegaly, lymphadenopathy and secrete high levels of IL-4

• these abnormal T cells promote B cell activation in their hosts leading to high levels of IgG1 and IgE

• T cells are not pathogenic when transferred into MHC-II deficient hosts or in the absence of CD28 signalling