Phenotypes Associated with This Genotype

Genotype
MGI:4356493

• Allelic Composition: Cd247^tm1Tks/Cd247^tm1Tks
• Genetic Background: B6.129P2-Cd247^tm1Tks

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased NK T cell number ( J:28282 )

• NK T cells numbers are decreased in the thymus

• alpha-beta NK T cells are virtually absent in the thymus while there is a six-fold increase in gamma-delta NK T cells

• these gamma-delta NK T cells have similar NK markers as their alpha-beta counterparts except most are CD4^-

abnormal NK cell morphology ( J:66403 )

• the expression of FcgRIII is increased on NK cells

abnormal NK cell physiology ( J:66403 )

• NK cells secrete increased amounts of IFN-gamma relative to controls in response to immobilized IgG

increased natural killer cell mediated cytotoxicity ( J:66403 )

• Ab-dependent cell-mediated cytotoxicity by NK cells is enhanced in these mice

• cytolytic activity against NK target cells is normal

increased interferon-gamma secretion ( J:66403 )

• NK cells secrete increased amounts of IFN-gamma relative to controls in response to immobilized IgG

hematopoietic system

decreased NK T cell number ( J:28282 )

• NK T cells numbers are decreased in the thymus

• alpha-beta NK T cells are virtually absent in the thymus while there is a six-fold increase in gamma-delta NK T cells

• these gamma-delta NK T cells have similar NK markers as their alpha-beta counterparts except most are CD4^-

abnormal NK cell morphology ( J:66403 )

• the expression of FcgRIII is increased on NK cells

abnormal NK cell physiology ( J:66403 )

• NK cells secrete increased amounts of IFN-gamma relative to controls in response to immobilized IgG

increased natural killer cell mediated cytotoxicity ( J:66403 )

• Ab-dependent cell-mediated cytotoxicity by NK cells is enhanced in these mice

• cytolytic activity against NK target cells is normal