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Phenotypes Associated with This Genotype
Genotype
MGI:4353429
Allelic
Composition		 Irf3tm1Ttg/Irf3tm1Ttg
Genetic
Background		 involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf3tm1Ttg mutation (3 available); any Irf3 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
decreased cellular sensitivity to ultraviolet irradiation induced cell death ( J:150948 )
• embryonic fibroblasts are resistant to apoptosis to caused by UV irradiation

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/26/2026
MGI 6.24 		The Jackson Laboratory