Phenotypes Associated with This Genotype

Genotype
MGI:3852376

• Allelic Composition: Fcamr^tm2Shib/Fcamr^tm2Shib
• Genetic Background: BALB/c-Fcamr^tm2Shib

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased spleen germinal center number ( J:150824 )

• immunization with a T cell-independent antigen causes formation germinal centers that are bigger and more numerous than in controls

increased spleen germinal center size ( J:150824 )

• immunization with a T cell-independent antigen causes formation germinal centers that are bigger and more numerous than in controls

abnormal marginal zone B cell physiology ( J:150824 )

• marginal zone B cells retain T cell-independent antigen at least 8 hours longer than wild-type controls

abnormal follicular dendritic cell antigen presentation ( J:150824 )

• follicular dendritic cells retain T cell-independent antigen on their cell surface 12 hours after immunization, which is longer than on wild-type controls

hematopoietic system

increased spleen germinal center number ( J:150824 )

• immunization with a T cell-independent antigen causes formation germinal centers that are bigger and more numerous than in controls

increased spleen germinal center size ( J:150824 )

• immunization with a T cell-independent antigen causes formation germinal centers that are bigger and more numerous than in controls

abnormal marginal zone B cell physiology ( J:150824 )

• marginal zone B cells retain T cell-independent antigen at least 8 hours longer than wild-type controls