Analysis Tools
nervous system
|
• decreased threshold for kainic acid induced seizures compared to control transgenic lines
|
|
• the ratio of sodium current densities in bipolar versus pyramidal neurons is reduced and the sodium current density in bipolar cells is reduced compared to controls
• sodium channels appear to recover more slowly from inactivation and current through the channels decreases during a series of depolarizations in bipolar neurons
• in pyramidal neurons a negative shift is seen in the voltage dependence of inactivation
|
behavior/neurological
|
• decreased threshold for kainic acid induced seizures compared to control transgenic lines
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| generalized epilepsy with febrile seizures plus | DOID:0060170 | J:150454 | ||
