Phenotypes Associated with This Genotype

Genotype
MGI:3850449

• Allelic Composition: Cdkn2a^tm1.1Brn/Cdkn2a⁺; Nf2^tm2Gth/Nf2^tm2Gth; Trp53^tm1Brn/Trp53^tm1Brn
• Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased metastatic potential ( J:132943 )

• following adenoviral cre treatment, the parietal pleura often shows invasion with concomitant pleural effusion

increased tumor incidence ( J:132943 )

• following adenoviral cre treatment, 94% of mice develop aggressive thoracic tumors (including malignant mesotheliomas, 15 of 51; and rhabdomyosarcomas, 1 of 51) with the parietal pleura often showing invasion with concomitant pleural effusion

• following adenoviral cre treatment, 1% of mice develop aspecific tumors not induced by adeno-cre treatment

increased rhabdomyosarcoma incidence ( J:132943 )

increased mesothelioma incidence ( J:132943 )

homeostasis/metabolism

pleural effusion ( J:132943 )

• following adenoviral cre treatment, the parietal pleura often shows invasion with concomitant pleural effusion

respiratory system

pleural effusion ( J:132943 )

• following adenoviral cre treatment, the parietal pleura often shows invasion with concomitant pleural effusion

muscle

increased rhabdomyosarcoma incidence ( J:132943 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
malignant mesothelioma		DOID:1790	OMIM:156240	J:132943