Phenotypes Associated with This Genotype

Genotype
MGI:3850122

• Allelic Composition: Smad9^tm3Jfm/Smad9^tm3Jfm
• Genetic Background: involves: 129S4/SvJaeSor

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

respiratory system

abnormal lung vasculature morphology ( J:150213 )

• beginning at 11.5 months of age vessels in the lung show signs of defective vascular remodeling

• in 6 of 15 mice, distal pulmonary arterioles show hyperplasia with vessel occlusion and plexiform lesions

lung inflammation ( J:150213 )

• perivascular inflammatory infiltrates are seen in the lungs

increased lung adenoma incidence ( J:150213 )

• seen in 3 of 19 mice

neoplasm

increased lung adenoma incidence ( J:150213 )

• seen in 3 of 19 mice

embryo

embryo phenotype ( J:150213 )

N • despite expression of the endogenous gene during development no gross developmental abnormalities are seen

cardiovascular system

abnormal lung vasculature morphology ( J:150213 )

• beginning at 11.5 months of age vessels in the lung show signs of defective vascular remodeling

• in 6 of 15 mice, distal pulmonary arterioles show hyperplasia with vessel occlusion and plexiform lesions

immune system

lung inflammation ( J:150213 )

• perivascular inflammatory infiltrates are seen in the lungs

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
primary pulmonary hypertension		DOID:14557	OMIM:178600 OMIM:265400 OMIM:615342 OMIM:615343 OMIM:615344	J:150213