Phenotypes Associated with This Genotype

Genotype
MGI:3847312

• Allelic Composition: Spast^M1Gri/Spast^M1Gri
• Genetic Background: B6.C-Spast^M1Gri

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal axon morphology ( J:148877 )

• mice exhibit axonal swelling containing stalled cargoes in cortical neurons unlike in wild-type mice

• however, axonal branching is normal

abnormal axonal transport ( J:148877 )

• anterograde axonal transport of mitochondria is reduced 25% and anterograde of APP-marked membrane bound organelles is decreased compared to in wild-type mice

behavior/neurological

abnormal gait ( J:148877 )

• at 7 and 12 months, mice exhibit increase in the hind limb base of support compared with wild-type mice

• however, mice exhibit normal muscle strength and motor coordination

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hereditary spastic paraplegia 4		DOID:0110792	OMIM:182601	J:148877