Analysis Tools
reproductive system
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• 10% of mice exhibit reduced fertility
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nervous system
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• 54% of mice have moderate defects including exencephaly, lack of neural tube closure, or microencephaly with midbrain and forebrain reduction
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• at E10.5, 65% of mice exhibit brain abnormalities of which 54% have moderate defects including exencephaly, lack of neural tube closure, or microencephaly with midbrain and forebrain reduction, and 11% have severe defects with heavy reduction of the forebrain and midbrain
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• while forebrain territory is initially established it is not properly maintained
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• while midbrain territory is initially established it is not properly maintained
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• the forebrain is reduced moderately to severely compared to in wild-type mice
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• the midbrain is reduced moderately to severely compared to in wild-type mice
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anencephaly
(
J:71034
)
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• mice exhibit anencephalic features
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exencephaly
(
J:71034
)
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• 54% of mice have moderate defects including exencephaly, lack of neural tube closure, or microencephaly with midbrain and forebrain reduction
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behavior/neurological
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• mice occasionally exhibit abnormal motor activity
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embryo
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• 54% of mice have moderate defects including exencephaly, lack of neural tube closure, or microencephaly with midbrain and forebrain reduction
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growth/size/body
microcephaly
(
J:71034
)
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• 54% of mice have moderate defects including exencephaly, lack of neural tube closure, or microencephaly with midbrain and forebrain reduction
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