Phenotypes Associated with This Genotype

Genotype
MGI:3843507

• Allelic Composition: Chrnb2^tm1Jpc/Chrnb2^tm1Jpc
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:23256 )

N • spontaneous locomotor activity is not significantly different in mutant and control mice

N • spatial learning and memory is not significantly different in mutant and control mice, as assayed by both the hidden platform and visible platform Morris water maze test

N • mice do not differ from controls in the ability to respond to pain; flinch, vocalization and jump response to foot shock is similar in mutant and control mice

impaired passive avoidance behavior ( J:23256 )

• basal levels of passive avoidance bahavior are similar in mutant and control mice; however, nicotine treatment in control mice results in increased retention latency while no effect is seen in the mutant mice

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:23256 )

N • mutant mice do not exhibit differences in heart rate or basal body temperature

nervous system

abnormal brain morphology ( J:23256 )

• nicotine binding sites are completely abolished in the brain of mutant mice

abnormal nicotine-mediated receptor currents ( J:23256 )

• whole cell recordings of anterior thalamic neurons derived from mutant mice show that these neurons fail to evoke current in response to nicotine