Phenotypes Associated with This Genotype

Genotype
MGI:3842939

• Allelic Composition: Tg(Vav-BCL2)69Jad/0
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:228913 )

• mice die around 13 months of age

immune system

enlarged spleen ( J:88565 )

abnormal class switch recombination ( J:88565 )

• the total number of B cells that undergo class switching is 50-fold higher than in wild-type mice

abnormal somatic hypermutation frequency ( J:88565 )

• 22 of 23 clones isolated from class-switching cells harbor on average about 6 somatic mutations compared to in wild-type cells where no mutations are found

abnormal lymphocyte cell number ( J:88565 )

• the ratio of CD4 cells per B cell is 25% to 50% lower than in wild-type mice

increased B cell number ( J:88565 )

• 5-fold higher in the spleen at 18 weeks

increased T cell number ( J:88565 )

• mice exhibit higher splenic T cell numbers than in wild-type and Tg(BCL2)22Wehi or Tg(BCL2)36Wehi mice

increased CD4-positive, alpha-beta T cell number ( J:88565 )

• the increase in CD4+ T cells is greater than the increase in CD8+ T cells

increased CD8-positive, alpha-beta T cell number ( J:88565 )

• the increase in CD4+ T cells is greater than the increase in CD8+ T cells

abnormal spleen germinal center morphology ( J:88565 )

• mice exhibit a larger pool of cycling B cells with a germinal center phenotype than in wild-type mice

• however, expansion of germinal centers is dependent on CD4 T cell help

• at 18 weeks, mice exhibit an increased in germinal center size and number compared to in wild-type mice

increased spleen germinal center number ( J:88565 )

• at 18 weeks

increased spleen germinal center size ( J:88565 )

• at 18 weeks

enlarged lymph nodes ( J:88565 )

glomerulonephritis ( J:88565 )

• at 40 weeks, 15% to 25% of mice develop autoimmune glomerulonephritis

neoplasm

increased tumor incidence ( J:88565 )

• 12% of mice develop plasma cell tumors

increased lymphoma incidence ( J:88565 )

• less than 10% of mice develop lymphoblastic lymphomas

increased T cell derived lymphoma incidence ( J:88565 )

• in less than 10% of mice

increased B cell derived lymphoma incidence ( J:88565 , J:228913 )

• less than 10% of mice develop large cell B lymphomas (J:88565)

• diffuse large B cell lymphoma (J:228913)

increased follicular lymphoma incidence ( J:88565 , J:228913 )

• at 18 months, 37% to 50% of mice develop monoclonal follicular lymphoma (J:88565)

increased histiocytic sarcoma incidence ( J:88565 )

• in less than 10% of mice

renal/urinary system

abnormal renal glomerulus morphology ( J:88565 )

• mice develop hypercellular glomeruli that contain amorphous, eosinophilic deposits

abnormal glomerular capillary morphology ( J:88565 )

• most capillaries are no longer patent

glomerulonephritis ( J:88565 )

• at 40 weeks, 15% to 25% of mice develop autoimmune glomerulonephritis

glomerular crescent ( J:88565 )

• Bowman epithelium proliferates to form crescents in the most advanced cases

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:88565 )

• in less than 10% of mice

hematopoietic system

enlarged spleen ( J:88565 )

abnormal class switch recombination ( J:88565 )

• the total number of B cells that undergo class switching is 50-fold higher than in wild-type mice

abnormal somatic hypermutation frequency ( J:88565 )

• 22 of 23 clones isolated from class-switching cells harbor on average about 6 somatic mutations compared to in wild-type cells where no mutations are found

abnormal lymphocyte cell number ( J:88565 )

• the ratio of CD4 cells per B cell is 25% to 50% lower than in wild-type mice

increased B cell number ( J:88565 )

• 5-fold higher in the spleen at 18 weeks

increased T cell number ( J:88565 )

• mice exhibit higher splenic T cell numbers than in wild-type and Tg(BCL2)22Wehi or Tg(BCL2)36Wehi mice

increased CD4-positive, alpha-beta T cell number ( J:88565 )

• the increase in CD4+ T cells is greater than the increase in CD8+ T cells

increased CD8-positive, alpha-beta T cell number ( J:88565 )

• the increase in CD4+ T cells is greater than the increase in CD8+ T cells

abnormal spleen germinal center morphology ( J:88565 )

• mice exhibit a larger pool of cycling B cells with a germinal center phenotype than in wild-type mice

• however, expansion of germinal centers is dependent on CD4 T cell help

• at 18 weeks, mice exhibit an increased in germinal center size and number compared to in wild-type mice

increased spleen germinal center number ( J:88565 )

• at 18 weeks

increased spleen germinal center size ( J:88565 )

• at 18 weeks

cardiovascular system

abnormal glomerular capillary morphology ( J:88565 )

• most capillaries are no longer patent

growth/size/body

enlarged spleen ( J:88565 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
follicular lymphoma		DOID:0050873	OMIM:151430	J:88565