Phenotypes Associated with This Genotype

Genotype
MGI:3842834

• Allelic Composition: Tg(KRT5-Akt1*)Jmpa/0
• Genetic Background: involves: C57BL/6 * DBA/2 * DBA/2J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased trichoepithelioma incidence ( J:144831 )

• mice exhibit palatine and tongue gland hyperplasia with signs of adenocarcinomatous conversion, in situ carcinomas of the oral mucosa, and lip trichoepithelioma

abnormal tumor morphology ( J:144831 )

• the number of blood vessels is enhanced in dysplasias and tumos compared to normal oral epithelia in Tg(KRT5-Akt1*)Jmpa mice

increased carcinoma incidence ( J:144831 )

• mice exhibit palatine and tongue gland hyperplasia with signs of adenocarcinomatous conversion, in situ carcinomas of the oral mucosa, and lip trichoepithelioma

increased adenocarcinoma incidence ( J:144831 )

• mice exhibit palatine and tongue gland hyperplasia with signs of adenocarcinomatous conversion, in situ carcinomas of the oral mucosa, and lip trichoepithelioma

increased squamous cell carcinoma incidence ( J:144831 )

• in 9 of 33 mice

digestive/alimentary system

abnormal oral mucosa morphology ( J:144831 )

• cell proliferation of nontumoral oral epithelia is mildly increased compared to in wild-type mice

• all mice develop pretumoral lesions in the oral cavity unlike wild-type mice

oral erythroplakia ( J:144831 )

• mice develop erythroplakia in the palate, cheeks, and lips unlike wild-type mice

oral leukoplakia ( J:144831 )

abnormal sublingual gland morphology ( J:144831 )

• hyperplastic with signs of adenocarcinomatous conversion, in situ carcinomas of the oral mucosa, and lip trichoepithelioma

abnormal palatine gland morphology ( J:144831 )

• hyperplastic with signs of adenocarcinomatous conversion, in situ carcinomas of the oral mucosa, and lip trichoepithelioma

cellular

decreased keratinocyte proliferation ( J:144831 )

• oral keratinocyte proliferation is arrested unlike in wild-type cells

increased cell proliferation ( J:144831 )

• cell proliferation of nonlesion oral epithelia is greater than in wild-type mice

craniofacial

abnormal oral mucosa morphology ( J:144831 )

• cell proliferation of nontumoral oral epithelia is mildly increased compared to in wild-type mice

• all mice develop pretumoral lesions in the oral cavity unlike wild-type mice

oral erythroplakia ( J:144831 )

• mice develop erythroplakia in the palate, cheeks, and lips unlike wild-type mice

oral leukoplakia ( J:144831 )

endocrine/exocrine glands

abnormal sublingual gland morphology ( J:144831 )

• hyperplastic with signs of adenocarcinomatous conversion, in situ carcinomas of the oral mucosa, and lip trichoepithelioma

abnormal palatine gland morphology ( J:144831 )

• hyperplastic with signs of adenocarcinomatous conversion, in situ carcinomas of the oral mucosa, and lip trichoepithelioma

integument

decreased keratinocyte proliferation ( J:144831 )

• oral keratinocyte proliferation is arrested unlike in wild-type cells

increased trichoepithelioma incidence ( J:144831 )

• mice exhibit palatine and tongue gland hyperplasia with signs of adenocarcinomatous conversion, in situ carcinomas of the oral mucosa, and lip trichoepithelioma

growth/size/body

abnormal oral mucosa morphology ( J:144831 )

• cell proliferation of nontumoral oral epithelia is mildly increased compared to in wild-type mice

• all mice develop pretumoral lesions in the oral cavity unlike wild-type mice

oral erythroplakia ( J:144831 )

• mice develop erythroplakia in the palate, cheeks, and lips unlike wild-type mice

oral leukoplakia ( J:144831 )