Phenotypes Associated with This Genotype

Genotype
MGI:3842177

hm3

• Allelic Composition: Npr2^cn/Npr2^cn
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Npr2^cn/Npr2^cn mice exhibit small body size.

skeleton

abnormal basicranium morphology ( J:5849 )

• endochondral bones are markedly reduced in length but not in width

abnormal mandibular condyloid process morphology ( J:5849 )

• cartilage is reduced

abnormal long bone epiphyseal plate morphology ( J:8099 )

• disruption of the proximal tibial plate

• Background Sensitivity: modifiers may be responsible for 2 non-overlapping groups of 22 day old mice homozygous mice in a segregating stock; one group with marginal, one with serious disruption of the proximal tibial growth plate

abnormal chondrocyte morphology ( J:15335 )

• a larger than normal accumulation of glycogen is seen

• many hypertrophic chondrocytes fail to degenerate

growth/size/body

abnormal mandibular condyloid process morphology ( J:5849 )

• cartilage is reduced

decreased body size ( J:359897 )

craniofacial

abnormal basicranium morphology ( J:5849 )

• endochondral bones are markedly reduced in length but not in width

abnormal mandibular condyloid process morphology ( J:5849 )

• cartilage is reduced