Phenotypes Associated with This Genotype

Genotype
MGI:3840833

• Allelic Composition: Rag1^tm1Jsek/Rag1⁺
• Genetic Background: involves: 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal B cell differentiation ( J:146912 )

• B cell development becomes impaired in mice over 1 year of age

• in the bone marrow of year old mice, significantly fewer B220⁺CD43⁺ pro-B cells progress to the B220⁺CD43^- pre-B and B220⁺IgM⁺ stages of development

abnormal immunoglobulin heavy chain V(D)J recombination ( J:146912 )

• IgH-D to IgH-J rearrangements are impaired in sorted pro-B- and pre-B-cell populations of mice one year of age compared to controls

abnormal T cell differentiation ( J:146912 )

• T cell development becomes impaired in mice over 1 year of age

• there is a significant decrease in the percentage and number of double-positive thymocytes of year old mice compared to age-matched wild-type controls

abnormal T cell receptor beta chain V(D)J recombination ( J:146912 )

• Dbeta to Jbeta rearrangements are impaired in thymocytes of mice over 1 year of age compared to controls

decreased double-positive T cell number ( J:146912 )

• there is a significant decrease in the percentage and number of double-positive thymocytes of year old mice compared to age-matched wild-type controls

hematopoietic system

abnormal B cell differentiation ( J:146912 )

• B cell development becomes impaired in mice over 1 year of age

• in the bone marrow of year old mice, significantly fewer B220⁺CD43⁺ pro-B cells progress to the B220⁺CD43^- pre-B and B220⁺IgM⁺ stages of development

abnormal immunoglobulin heavy chain V(D)J recombination ( J:146912 )

• IgH-D to IgH-J rearrangements are impaired in sorted pro-B- and pre-B-cell populations of mice one year of age compared to controls

abnormal T cell differentiation ( J:146912 )

• T cell development becomes impaired in mice over 1 year of age

• there is a significant decrease in the percentage and number of double-positive thymocytes of year old mice compared to age-matched wild-type controls

abnormal T cell receptor beta chain V(D)J recombination ( J:146912 )

• Dbeta to Jbeta rearrangements are impaired in thymocytes of mice over 1 year of age compared to controls

decreased double-positive T cell number ( J:146912 )

• there is a significant decrease in the percentage and number of double-positive thymocytes of year old mice compared to age-matched wild-type controls