Analysis Tools
immune system
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• mice have severe splenomegaly by 10 months of age with cellularity at least 3-fold greater than in controls
• increases size is from an increased number of memory CD4+ T cells and B cells
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• increased mature B cell numbers are found in the spleen of 10 month old mice
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• increased memory/effector (CD4+ CD44+) T cells are found in the spleen of 10 month old mice
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• sera levels of IgG1 are 10-fold higher in mice 10 months of age
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• sera levels of IgM are 10-fold higher in mice 10 months of age
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• a large amount of anti-dsDNA IgM and IgG1 is found in the sera of 10 month old mice
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• a large amount of anti-histone IgM and IgG1 is found in the sera of 10 month old mice
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• immune complex deposits are found in the glomeruli of 10 month old mice
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renal/urinary system
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• immune complex deposits are found in the glomeruli of 10 month old mice
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hematopoietic system
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• mice have severe splenomegaly by 10 months of age with cellularity at least 3-fold greater than in controls
• increases size is from an increased number of memory CD4+ T cells and B cells
|
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• increased mature B cell numbers are found in the spleen of 10 month old mice
|
|
• increased memory/effector (CD4+ CD44+) T cells are found in the spleen of 10 month old mice
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• sera levels of IgG1 are 10-fold higher in mice 10 months of age
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• sera levels of IgM are 10-fold higher in mice 10 months of age
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growth/size/body
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• mice have severe splenomegaly by 10 months of age with cellularity at least 3-fold greater than in controls
• increases size is from an increased number of memory CD4+ T cells and B cells
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