Phenotypes Associated with This Genotype

Genotype
MGI:3839866

ht4

• Allelic Composition: Trp53bp2^tm1Cdlo/Trp53bp2⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased tumor incidence ( J:146764 )

• increased tumor incidence but the spectrum of tumor types is similar to controls

increased incidence of tumors by ionizing radiation induction ( J:146764 )

• unlike wild-type controls, mice develop tumors following exposure to 6.0 Gy or 10.5 Gy of gamma-radiation

• induced tumors are high grade lymphomas

immune system

abnormal T cell physiology ( J:146764 )

• attenuated T cell apoptotic response following gamma-irradiation

cellular

abnormal cell cycle checkpoint function ( J:146764 )

• attenuated G0/G1 checkpoint function following gamma-irradiation

hematopoietic system

abnormal T cell physiology ( J:146764 )

• attenuated T cell apoptotic response following gamma-irradiation

homeostasis/metabolism

increased incidence of tumors by ionizing radiation induction ( J:146764 )

• unlike wild-type controls, mice develop tumors following exposure to 6.0 Gy or 10.5 Gy of gamma-radiation

• induced tumors are high grade lymphomas