Analysis Tools
mortality/aging
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• some mice die between E14.5 and E18.5
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• about half die before weaning from loss pulmonary or cardiac vascular integrity
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• some mice die between E10.5 and E14.5
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cardiovascular system
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• at mid gestation some mice display invagination of the ventricular cavity into and often through the compact layer of the ventricular myocardium
• the septal myocardium also contains endothelial lined extensions from the ventricular cavity
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• rupture of the atria is seen in some mice
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• in late gestation embryos ventricular septal defects accompany the presence of endothelial lined extensions from the ventricular cavity within the septum
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• resulting from atrial rupture
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• lymphatic vessels leak chyle into the intestinal wall and peritoneal space
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homeostasis/metabolism
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• resulting from atrial rupture
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• chylous ascites form in about 10% of mice shortly after their first feeding
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immune system
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• lymphatic vessels leak chyle into the intestinal wall and peritoneal space
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• endothelial cell junctions are markedly shorter compared to controls and accompanied by endothelial gaps not seen in controls
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• the presence of chylous ascites is always associated with the presence of severely dilated intestinal and mesenteric lymphatic vessels
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respiratory system
