Phenotypes Associated with This Genotype

Genotype
MGI:3836163

• Allelic Composition: Prph2^tm1Nmc/Prph2^tm1Nmc
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

increased retina apoptosis ( J:76490 )

• at 5 weeks, mice exhibit an increase in apoptosis in the outer nuclear layer unlike in wild-type mice

decreased retina rod cell number ( J:76490 )

absent photoreceptor outer segment ( J:76490 )

thin retina outer nuclear layer ( J:76490 )

• at 5 weeks, the outer nuclear layer is only 3 or 4 nuclei thick unlike in wild-type mice

abnormal retina outer plexiform layer morphology ( J:76490 )

increased susceptibility to age-related retinal degeneration ( J:76490 )

• mice exhibit 4 or 5 rows of photoreceptor nuclei at 1 month and 1 row at 4 months

abnormal rod electrophysiology ( J:76490 )

• absent at 1 month of age

nervous system

decreased retina rod cell number ( J:76490 )

absent photoreceptor outer segment ( J:76490 )

cellular

increased retina apoptosis ( J:76490 )

• at 5 weeks, mice exhibit an increase in apoptosis in the outer nuclear layer unlike in wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
retinitis pigmentosa 7		DOID:0110383	OMIM:608133	J:76490