Phenotypes Associated with This Genotype

Genotype
MGI:3833579

cn162

• Allelic Composition: Gt(ROSA)26Sor^{tm3(CAG-Il17a)Awai}/Gt(ROSA)26Sor⁺; Tg(Cd4-cre)1Cwi/0
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased granulocyte number ( J:144710 )

• there is a minor but significant increase in the number of granulocytes in the blood

abnormal immune system physiology ( J:144710 )

• despite high levels of IL-17A expression by T cells, there is no difference in onset or severity of experimental autoimmune encephalomyelitis induced by myelin oligodendrocyte glycoprotein peptide (MOG) compared to controls

abnormal neutrophil physiology ( J:144710 )

• increased numbers of neutrophils are recruited into the spleen compared to controls after immunization with MOG peptide

increased circulating interleukin-17 level ( J:144710 )

• immunization with MOG peptide plus adjuvant leads a highly significant increase in serum IL-17A levels

increased interleukin-17 secretion ( J:144710 )

• T cells constitutively express high levels of IL-17A

• this secretion is greatly enhanced after T cell stimulation

homeostasis/metabolism

increased circulating interleukin-17 level ( J:144710 )

• immunization with MOG peptide plus adjuvant leads a highly significant increase in serum IL-17A levels

hematopoietic system

increased granulocyte number ( J:144710 )

• there is a minor but significant increase in the number of granulocytes in the blood

abnormal neutrophil physiology ( J:144710 )

• increased numbers of neutrophils are recruited into the spleen compared to controls after immunization with MOG peptide