Phenotypes Associated with This Genotype

Genotype
MGI:3832410

• Allelic Composition: Prlh^tm1Taon/Prlh^tm1Taon
• Genetic Background: B6N.129X1-Prlh^tm1Taon

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

increased body weight ( J:144729 )

• become significantly heavier by 18 weeks of age when fed a normal chow diet ad libitum

• body weight gain is more prominent when fed a high fat diet ad libitum

• when food intake is restricted to match mean food intake of wild-type controls body weight is not significantly different from wild-type controls

obese ( J:144729 )

• adult onset obesity

increased susceptibility to diet-induced obesity ( J:144729 )

• become significantly heavier when fed a high fat diet compared to wild-type controls

adipose tissue

increased brown adipose tissue amount ( J:144729 )

increased white adipose tissue amount ( J:144729 )

• increase in both subcutaneous and intraabdominal fat pad masses

increased fat cell size ( J:144729 )

• epididymal adipocytes are increased in size

behavior/neurological

behavior/neurological phenotype ( J:144729 )

N • no significant difference in home cage activity levels compared to wild-type controls

increased food intake ( J:144729 )

• seen on both normal chow and high fat diets

• seen at 24 weeks of age but not before 14 weeks of age

• impairment in reduction in food intake following peripheral or central leptin administration

increased compensatory feeding amount ( J:144729 )

• feeding after a fast is increased at 14 weeks of age

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:144729 )

N • no significant difference in oxygen consumption or mean respiratory exchange ratios compared to wild-type controls

increased susceptibility to diet-induced obesity ( J:144729 )

• become significantly heavier when fed a high fat diet compared to wild-type controls

increased circulating insulin level ( J:144729 )

increased circulating leptin level ( J:144729 )

increased circulating triglyceride level ( J:144729 )

impaired glucose tolerance ( J:144729 )

• in mice fed a normal chow diet ad libitum

• when food intake is restricted to match mean food intake of wild-type controls glucose tolerance is similar to wild-type controls

insulin resistance ( J:144729 )

• in mice fed a normal chow diet ad libitum

• when food intake is restricted to match mean food intake of wild-type controls insulin sensitivity is similar to wild-type controls

increased liver triglyceride level ( J:144729 )

• increase in hepatic triglyceride levels

liver/biliary system

increased liver triglyceride level ( J:144729 )

• increase in hepatic triglyceride levels

hepatic steatosis ( J:144729 )

nervous system

abnormal autonomic nervous system physiology ( J:144729 )

• after refeeding there is no significant increase in the percentage of p-CREB-positive PRLH neurons in the ventrolateral medulla oblongota or in the dorsomedial hypothalamus suggesting impaired activation of these neurons

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
obesity		DOID:9970	OMIM:601665	J:144729