Analysis Tools
mortality/aging
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• when this allele is inherited maternally, most mice die around the time of birth but some survive
• Background Sensitivity: survival rate is dependent on strain background
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• when this allele is inherited maternally, most mice die around the time of birth but some survive
• however, when this allele is inherited paternally no abnormal lethality is observed
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• when this allele is inherited maternally, some mice die postnatally
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reproductive system
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• when this allele is inherited maternally, 10 of 16 surviving females exhibit distention of the uterus due to an imperforate vagina
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• when this allele is inherited maternally, 10 of 16 surviving females exhibit a 6-fold increase in uterus size compared to in wild-type mice
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• when this allele is inherited maternally, 10 of 16 surviving females exhibit distention of the uterus due to an imperforate vagina
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• when this allele is inherited maternally, 2 of 3 females are infertile
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• when this allele is inherited maternally, 1 of 6 males is infertile
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cardiovascular system
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• when this allele is inherited maternally, the ventricular septum width is increased compared to in wild-type mice
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• when this allele is inherited maternally
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• when this allele is inherited maternally, heart weight is 4-fold more than in wild-type mice
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• when this allele is inherited maternally
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• when this allele is inherited maternally, mice exhibit a 38% increase in mural thickening of the left ventricle compared to in wild-type mice without hyperplasia
• when this allele is inherited maternally, mice exhibit a 4-fold larger wall volume compared to in wild-type mice
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• an 89% increase compared to in wild-type mice when this allele is inherited maternally
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• when this allele is inherited maternally
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• when this allele is inherited maternally, perinatal lethality is likely caused by decompensated heart failure
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homeostasis/metabolism
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• when this allele is inherited maternally, IGF-II serum levels are 4.4-fold higher than in wild-type mice
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• when this allele is inherited maternally, mice are edematous at E17.5 and E18.5 unlike wild-type mice
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growth/size/body
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• when this allele is inherited maternally
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• when this allele is inherited maternally, heart weight is 4-fold more than in wild-type mice
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• when this allele is inherited maternally
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• beginning at E13.5 when this allele is inherited maternally
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• when this allele is inherited maternally, mice are 35% to 40% larger than wild-type mice at birth
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• when this allele is inherited maternally, water content at E17.5 and E18.5 is increased compared to in wild-type mice
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• when this allele is inherited maternally, mice are 35% to 40% larger than wild-type mice at E18.5
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• when this allele is inherited maternally
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enlarged lung
(
J:34584
)
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• when this allele is inherited maternally
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• when this allele is inherited maternally
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• when this allele is inherited maternally
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• when this allele is inherited maternally
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limbs/digits/tail
polydactyly
(
J:34584
)
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• postaxial when this allele is inherited maternally
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kinked tail
(
J:34584
)
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• when this allele is inherited maternally
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embryo
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• beginning at E13.5 when this allele is inherited maternally
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• beginning at E13.5 when this allele is inherited maternally
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liver/biliary system
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• when this allele is inherited maternally
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• when this allele is inherited maternally
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nervous system
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• when this allele is inherited maternally
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renal/urinary system
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• when this allele is inherited maternally
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hematopoietic system
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• when this allele is inherited maternally, immature (nucleated) red blood cells persist in the embryonic circulation unlike in wild-type mice
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respiratory system
enlarged lung
(
J:34584
)
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• when this allele is inherited maternally
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• when this allele is inherited maternally
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