Phenotypes Associated with This Genotype

Genotype
MGI:3818749

cx45

• Allelic Composition: Rag1^tm1Mom/Rag1^tm1Mom; Trp53^tm1Brd/Trp53^tm1Brd
• Genetic Background: involves: 129S7/SvEvBrd * C57BL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:141515 )

• all mice die by 45 weeks of age

neoplasm

increased pituitary adenoma incidence ( J:141515 )

• in one mouse

increased T cell derived lymphoma incidence ( J:141515 )

• 53% mice develop T cell lymphomas

increased hepatocellular carcinoma incidence ( J:141515 )

• in one mouse

increased medulloblastoma incidence ( J:141515 )

• mice that exhibit vertigo develop medulloblastoma

• 8.1% of mice exhibit medulloblastoma at the time of morbidity

increased sarcoma incidence ( J:141515 )

• in one mouse

increased hemangiosarcoma incidence ( J:141515 )

• in one mouse

respiratory system

respiratory distress ( J:141515 )

• in two-thirds of mice

behavior/neurological

impaired balance ( J:141515 )

• one mouse exhibited an acute onset of vertigo that led to disabled mobility and severe dehydration as a result of inability to reach the water source

homeostasis/metabolism

dehydration ( J:141515 )

• one mouse exhibited an acute onset of vertigo that led to disabled mobility and severe dehydration as a result of inability to reach the water source

nervous system

increased pituitary adenoma incidence ( J:141515 )

• in one mouse

increased medulloblastoma incidence ( J:141515 )

• mice that exhibit vertigo develop medulloblastoma

• 8.1% of mice exhibit medulloblastoma at the time of morbidity

endocrine/exocrine glands

increased pituitary adenoma incidence ( J:141515 )

• in one mouse

increased T cell derived lymphoma incidence ( J:141515 )

• 53% mice develop T cell lymphomas

liver/biliary system

increased hepatocellular carcinoma incidence ( J:141515 )

• in one mouse

hematopoietic system

increased T cell derived lymphoma incidence ( J:141515 )

• 53% mice develop T cell lymphomas

immune system

increased T cell derived lymphoma incidence ( J:141515 )

• 53% mice develop T cell lymphomas