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Phenotypes Associated with This Genotype
Genotype
MGI:3818443
Allelic
Composition		 Cd247tm1Mhu/Cd247tm1Mhu
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd247tm1Mhu mutation (0 available); any Cd247 mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:15579 )
N
• despite the reduction in T cell differentiation in the thymus, the numbers and ratios of CD4+ or CD8+ T cells in the spleen and lymph nodes, VDJ rearrangement, and the numbers and function of NK cells are normal
decreased T cell proliferation ( J:15579 )
• intraepithelial lymphocytes fail to proliferate in response to stimulation with anti-CD3 antibodies and ConA unlike heterozygous cells
decreased splenocyte proliferation ( J:15579 )
• TCR/CD3very low CD4+ and CD8+ single positive splenocytes fail to proliferate in response to anti-CD3 antibodies and ConA unlike heterozygous cells
enlarged thymus cortex ( J:15579 )
• the size of the cortex is enlarged at the expense of the medulla
small thymus medulla ( J:15579 )
• the medulla is restricted to small regions unlike in heterozygous mice
decreased thymocyte number ( J:15579 )
• at 8 to 12 weeks, thymocyte number is decreased 5- to 10-fold compared to in heterozygous mice
abnormal T cell differentiation ( J:15579 )
• mice exhibit a delayed and reduced differentiation of double negative T cells into double positive TCR/CD3hi T cells in the thymus compared to in heterozygous mice instead generating TCR/CD3very low CD4+ and CD8+ single positive T cells
• however, intraepithelial lymphocytes express normal levels of TCR/CD3
increased double-negative T cell number ( J:15579 )
• the percentage of double negative cells in the thymus is more than in heterozygous mice
• however, the absolute number of double negative cells is normal
decreased double-positive T cell number ( J:15579 )
• the percentage of double positive cells in the thymus is decreased compared to in heterozygotes
decreased CD4-positive, alpha-beta T cell number ( J:15579 )
• the percentage of CD4+ single positive cells in the thymus is decreased compared to in heterozygous mice mice that are indistinguishable from wild-type mice
decreased CD8-positive, alpha-beta T cell number ( J:15579 )
• the percentage of CD8+ single positive cells in the thymus is decreased compared to in heterozygous mice

hematopoietic system
decreased T cell proliferation ( J:15579 )
• intraepithelial lymphocytes fail to proliferate in response to stimulation with anti-CD3 antibodies and ConA unlike heterozygous cells
decreased splenocyte proliferation ( J:15579 )
• TCR/CD3very low CD4+ and CD8+ single positive splenocytes fail to proliferate in response to anti-CD3 antibodies and ConA unlike heterozygous cells
enlarged thymus cortex ( J:15579 )
• the size of the cortex is enlarged at the expense of the medulla
small thymus medulla ( J:15579 )
• the medulla is restricted to small regions unlike in heterozygous mice
decreased thymocyte number ( J:15579 )
• at 8 to 12 weeks, thymocyte number is decreased 5- to 10-fold compared to in heterozygous mice
abnormal T cell differentiation ( J:15579 )
• mice exhibit a delayed and reduced differentiation of double negative T cells into double positive TCR/CD3hi T cells in the thymus compared to in heterozygous mice instead generating TCR/CD3very low CD4+ and CD8+ single positive T cells
• however, intraepithelial lymphocytes express normal levels of TCR/CD3
increased double-negative T cell number ( J:15579 )
• the percentage of double negative cells in the thymus is more than in heterozygous mice
• however, the absolute number of double negative cells is normal
decreased double-positive T cell number ( J:15579 )
• the percentage of double positive cells in the thymus is decreased compared to in heterozygotes
decreased CD4-positive, alpha-beta T cell number ( J:15579 )
• the percentage of CD4+ single positive cells in the thymus is decreased compared to in heterozygous mice mice that are indistinguishable from wild-type mice
decreased CD8-positive, alpha-beta T cell number ( J:15579 )
• the percentage of CD8+ single positive cells in the thymus is decreased compared to in heterozygous mice

cellular
decreased T cell proliferation ( J:15579 )
• intraepithelial lymphocytes fail to proliferate in response to stimulation with anti-CD3 antibodies and ConA unlike heterozygous cells
decreased splenocyte proliferation ( J:15579 )
• TCR/CD3very low CD4+ and CD8+ single positive splenocytes fail to proliferate in response to anti-CD3 antibodies and ConA unlike heterozygous cells

endocrine/exocrine glands
enlarged thymus cortex ( J:15579 )
• the size of the cortex is enlarged at the expense of the medulla
small thymus medulla ( J:15579 )
• the medulla is restricted to small regions unlike in heterozygous mice
decreased thymocyte number ( J:15579 )
• at 8 to 12 weeks, thymocyte number is decreased 5- to 10-fold compared to in heterozygous mice

growth/size/body
enlarged spleen ( J:15579 )

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/26/2026
MGI 6.24 		The Jackson Laboratory