Phenotypes Associated with This Genotype

Genotype
MGI:3815301

• Allelic Composition: Tsc1^tm1Djk/Tsc1^tm1Djk; Tg(Pax8-rtTA2S*M2)1Koes/0; Tg(tetO-cre)LC1Bjd/0
• Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:140925 )

• following exposure to doxycycline in utero, mice die 3 to 4 weeks after birth with giant polycystic kidneys

renal/urinary system

polycystic kidney ( J:140925 )

• following exposure to doxycycline in utero, newborn mice exhibit fulminant cysts and giant polycystic kidneys form by 3 to 4 weeks of age

kidney epithelium hyperplasia ( J:140925 )

• following exposure to doxycycline in utero, new born mice exhibit hyperplasia of the proximal and distal tubules and collecting duct epithelium

growth/size/body

polycystic kidney ( J:140925 )

• following exposure to doxycycline in utero, newborn mice exhibit fulminant cysts and giant polycystic kidneys form by 3 to 4 weeks of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autosomal recessive polycystic kidney disease		DOID:0110861	OMIM:263200	J:140925