Phenotypes Associated with This Genotype

Genotype
MGI:3814581

• Allelic Composition: Tg(MT1A-Dyrk1a)#Xest/0
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal behavior ( J:71821 )

• mice exhibit retardation of development in a homing test with increased latency to reach the goal arena compared to wild-type mice

decreased anxiety-related response ( J:71821 )

• mice spend more time than wild-type mice in the arms of an elevated plus maze and exhibit reduced emotionality

impaired coordination ( J:71821 , J:140647 )

• in a wire suspension test, P14 mice exhibit a reduced latency to fall compared to wild-type mice (J:71821)

• in the coat hanger test, adult mice exhibit a reduced latency to fall compared to wild-type mice and the number of crossing along the bar was reduced compared to in wild-type mice (J:71821)

• mice perform poorly on a treadmill test (J:140647)

• however, treatment of mice with an adenovirus expressing a short hairpin RNA targeting Dyrk1a can rescue normal coordination (J:140647)

abnormal locomotor behavior ( J:71821 )

• in a pivoting test, mice exhibit more turnings at P10 than wild-type mice

• mice exhibit a delay in acquisition and maturation of locomotion from cranial to caudal parts of the body

abnormal locomotor activation ( J:71821 )

• at P7, mice exhibit an increased latency to initiate walking compared to wild-type mice

abnormal gait ( J:71821 )

• mice exhibit a delay in maturation of gait and a persistence of immature locomotor patterns

hyperactivity ( J:140647 )

• mice exhibit increased activity

• however, treatment of mice with an adenovirus expressing a short hairpin RNA targeting Dyrk1a can rescue normal activity levels

increased locomotor activity ( J:71821 )

• mice exhibit increased activity in the periphery and center of the arena in an open field test and in an elevated plus maze comapred to wild-type mice

nervous system

abnormal paired-pulse inhibition ( J:140647 )

• mice exhibit a decrease in the paired pulse inhibition levels compared to wild type mice

• however, treatment of mice with an adenovirus expressing a short hairpin RNA targeting Dyrk1a can rescue normal paired pulse inhibition levels

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Down syndrome		DOID:14250	OMIM:190685	J:71821