Phenotypes Associated with This Genotype

Genotype
MGI:3814544

ht1

• Allelic Composition: Trp53^tm1Ldo/Trp53⁺
• Genetic Background: B6.129S7-Trp53^tm1Ldo

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased circulating insulin-like growth factor I level ( J:130123 )

• serum IGF-1 levels are 34% of wild-type

endocrine/exocrine glands

abnormal mammary gland development ( J:130123 )

♀ • at 8, 12 and 24 weeks of age, mammary duct outgrowth is reduced compared to in wild-type mice

♀ • however, proliferation and apoptosis are normal throughout development, pregnancy and involution and treatment with hormones or by cross mice to Tg(TTR-Igf1)1Jxu mice rescues outgrowth

♀ • wild type mammary tissue transplanted into mice exhibits reduced outgrowth

♀ • serial transplants of mammary epithelium exhibit decreased transplant capabilities compared to wild-type epithelium

integument

abnormal mammary gland development ( J:130123 )

♀ • at 8, 12 and 24 weeks of age, mammary duct outgrowth is reduced compared to in wild-type mice

♀ • however, proliferation and apoptosis are normal throughout development, pregnancy and involution and treatment with hormones or by cross mice to Tg(TTR-Igf1)1Jxu mice rescues outgrowth

♀ • wild type mammary tissue transplanted into mice exhibits reduced outgrowth

♀ • serial transplants of mammary epithelium exhibit decreased transplant capabilities compared to wild-type epithelium