Phenotypes Associated with This Genotype

Genotype
MGI:3814538

ht3

• Allelic Composition: Trp53^tm1Brd/Trp53^tm1Ldo
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:73757 )

• mice survive 9 to 10 months

neoplasm

increased tumor incidence ( J:73757 )

• tumorigenesis is slightly delayed compared to in Trp53^tm1Brd homozygotes but mice still exhibit an increase in the numbers of T-cell lymphomas and soft tissue sarcomas compared to in wild-type mice

increased T cell derived lymphoma incidence ( J:73757 )

increased sarcoma incidence ( J:73757 )

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:73757 )

hematopoietic system

increased T cell derived lymphoma incidence ( J:73757 )

immune system

increased T cell derived lymphoma incidence ( J:73757 )