Analysis Tools
nervous system
|
• striatal tyrosine hydroxylase expression is markedly reduced in the caudoputamen and in the lateral part of the olfactory tubercle but not in the nucleus accumbens
• loss of tyrosine hydroxylase expression results from progressive postnatal loss of expression and failure to increase expression with maturation
|
|
• responses to stimulation with a dopamine agonist suggest dopaminergic hypersensitivity in the striatum particularly in the striosomes
|
behavior/neurological
|
• first detected at 2 weeks of age
|
|
• in balance beam tests mice are slower and make more foot slips
|
muscle
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| dystonia | DOID:543 |
OMIM:PS128100 |
J:138968 | |
