Phenotypes Associated with This Genotype

Genotype
MGI:3813482

• Allelic Composition: Tg(Ppp1r1b-HTT*)1Meeh/0
• Genetic Background: C57BL/6J-Tg(Ppp1r1b-HTT*)1Meeh

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

decreased brain weight ( J:139807 )

• at 22 months of age, forebrain weight is decreased compared to in wild-type mice

• however, striatal cellular morphology is normal

small lateral ventricles ( J:139807 )

• as mice age, lateral ventricles are progressively smaller in size than in wild-type mice

neuronal intranuclear inclusions ( J:139807 )

• at 6 months of age, mice exhibit intranuclear inclusion bodies that progressively increase in size and number as mice age

• at 8.5 months of age, inclusions are detected in Purkinje cells but are less numerous at 22 months of age

behavior/neurological

impaired coordination ( J:139807 )

• female mice exhibit impaired performance on a rotarod compared to wild-type mice that progressively worsens between 10 and 16 months

• male mice exhibit impaired performance on a rotarod compared to wild-type mice

decreased locomotor activity ( J:139807 )

• male mice exhibit decreased locomotor activity compared to wild-type mice that is most pronounced in the first 5 minutes of testing

growth/size/body

slow postnatal weight gain ( J:139807 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Huntington's disease		DOID:12858	OMIM:143100	J:139807