Analysis Tools
mortality/aging
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• mice die rapidly after birth and by P10 to P14 no mice are alive
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• though present in Mendelian ratios at E20, mice die rapidly after birth
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cellular
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• mouse embryonic fibroblasts (MEFs) subjected to UV irradiation and staurosporine fail to exhibit evidence of normal apoptosis 24hrs after treatment unlike in wild type MEFs
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• following injection of fetal liver cells into a RAG-deficient background, thymocyte apoptosis induced by mitochondrial pathways is decreased
• however, thymocytes are still sensitive to death receptor mediated apoptosis
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• mouse embryonic fibroblasts (MEFs) subjected to UV irradiation and staurosporine fail to undergo apoptosis
• MEFs exhibit decreased apoptosis following stimulation of the death receptor pathway
• following induction of apoptosis, MEFs fail to exhibit a loss of mitochondrial membrane potential
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cardiovascular system
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• at E20
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• at E20, the ventricular wall is disorganized and noncompacted
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nervous system
exencephaly
(
J:105496
)
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• in 10% of mice
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immune system
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• following injection of fetal liver cells into a RAG-deficient background, thymocyte apoptosis induced by mitochondrial pathways is decreased
• however, thymocytes are still sensitive to death receptor mediated apoptosis
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hematopoietic system
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• following injection of fetal liver cells into a RAG-deficient background, thymocyte apoptosis induced by mitochondrial pathways is decreased
• however, thymocytes are still sensitive to death receptor mediated apoptosis
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endocrine/exocrine glands
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• following injection of fetal liver cells into a RAG-deficient background, thymocyte apoptosis induced by mitochondrial pathways is decreased
• however, thymocytes are still sensitive to death receptor mediated apoptosis
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