Phenotypes Associated with This Genotype

Genotype
MGI:3810970

• Allelic Composition: Casp3^tm1Flv/Casp3^tm1Flv; Casp7^tm1Flv/Casp7⁺
• Genetic Background: B6.129S-Casp3^tm1Flv Casp7^tm1Flv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

decreased sensitivity to induced cell death ( J:105496 )

• mouse embryonic fibroblasts (MEFs) subjected to UV irradiation and staurosporine exhibit distorted chromosome condensation and nuclear fragmentation is absent unlike in similarly treated MEFs

decreased thymocyte apoptosis ( J:105496 )

• following injection of fetal liver cells into a RAG-deficient background, thymocyte apoptosis induced by mitochondrial pathways is decreased although not as much as in Casp3^tm1Flv Casp7^tm1Flv homozygous T cells

decreased fibroblast apoptosis ( J:105496 )

• apoptosis is decreased in mouse embryonic fibroblasts (MEFs) subjected to UV irradiation and staurosporine comapred to in wild-type MEFs

• MEFs exhibit decreased apoptosis following stimulation of the death receptor pathway that is intermediate to the response observed in Casp3^tm1Flv Casp7^tm1Flv homozygous MEFs

immune system

decreased thymocyte apoptosis ( J:105496 )

• following injection of fetal liver cells into a RAG-deficient background, thymocyte apoptosis induced by mitochondrial pathways is decreased although not as much as in Casp3^tm1Flv Casp7^tm1Flv homozygous T cells

hematopoietic system

decreased thymocyte apoptosis ( J:105496 )

• following injection of fetal liver cells into a RAG-deficient background, thymocyte apoptosis induced by mitochondrial pathways is decreased although not as much as in Casp3^tm1Flv Casp7^tm1Flv homozygous T cells

endocrine/exocrine glands

decreased thymocyte apoptosis ( J:105496 )

• following injection of fetal liver cells into a RAG-deficient background, thymocyte apoptosis induced by mitochondrial pathways is decreased although not as much as in Casp3^tm1Flv Casp7^tm1Flv homozygous T cells