Phenotypes Associated with This Genotype

Genotype
MGI:3807714

• Allelic
  Composition
• Genetic Background: A/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hearing/vestibular/ear

cochlear hair cell degeneration ( J:139222 )

• at 30 days of age a hair cell lesion is found in the basal turn of the cochlea in A/J although the spiral ganglion appear normal in all turns including the basal turn

• at 9 weeks of age there is a massive loss of inner and outer hair cells from the mid-basal turn of the cochlea and a moderate loss of inner and outer hair cells from the mid-apical turn

• at 20 weeks of age there is a massive loss of inner and outer hair cells throughout the cochlea, except for the apical 10%

• loss of cochlear hair cells begins around 16 days of age, spreads from base to apex, and outer hair cells are more vulnerable to loss than are inner hair cells

nervous system

cochlear hair cell degeneration ( J:139222 )

• at 30 days of age a hair cell lesion is found in the basal turn of the cochlea in A/J although the spiral ganglion appear normal in all turns including the basal turn

• at 9 weeks of age there is a massive loss of inner and outer hair cells from the mid-basal turn of the cochlea and a moderate loss of inner and outer hair cells from the mid-apical turn

• at 20 weeks of age there is a massive loss of inner and outer hair cells throughout the cochlea, except for the apical 10%

• loss of cochlear hair cells begins around 16 days of age, spreads from base to apex, and outer hair cells are more vulnerable to loss than are inner hair cells

immune system

abnormal neutrophil physiology ( J:51631 )

• subsequent to ip injection of 15mg/kg LPS, A/J mice show highly diminished neutrophil infiltration into hepatic sinusoids compared with C57BL/6J controls

decreased acute inflammation ( J:51631 )

• subsequent to ip injection of 15mg/kg LPS, A/J mice have decreased hepatic, pulmonary and intestinal neutrophil infiltrate compared with C57BL/6J mice

increased susceptibility to Coronaviridae infection ( J:268979 )

• moderately susceptible to mouse-adapted SARS-CoV infection, including moderate and transient weight loss

hematopoietic system

abnormal neutrophil physiology ( J:51631 )

• subsequent to ip injection of 15mg/kg LPS, A/J mice show highly diminished neutrophil infiltration into hepatic sinusoids compared with C57BL/6J controls