Phenotypes Associated with This Genotype

Genotype
MGI:3807505

• Allelic Composition: Zfp148^Gt(XB878)Byg/Zfp148^Gt(XB878)Byg
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:133931 )

• embryos are recovered at normal ratios and are indistinguishable from littermates at E8.5, but all homozygous embryos are dead by E10.5

growth/size/body

embryonic growth retardation ( J:133931 )

• embryos recovered around E10.5 appear significantly growth retarded

embryo

abnormal vitelline vasculature morphology ( J:133931 )

• yolk sac vasculature is disorganized, and some lack visible red blood cells whereas some contain only small pools of primitive erythrocytes around E9.5-10.5

embryonic growth retardation ( J:133931 )

• embryos recovered around E10.5 appear significantly growth retarded

open neural tube ( J:133931 )

• embryos recovered around E10.5 display open neural tubes

nervous system

open neural tube ( J:133931 )

• embryos recovered around E10.5 display open neural tubes

cardiovascular system

abnormal vitelline vasculature morphology ( J:133931 )

• yolk sac vasculature is disorganized, and some lack visible red blood cells whereas some contain only small pools of primitive erythrocytes around E9.5-10.5

integument

pallor ( J:133931 )

• embryos recovered around E10.5 are markedly pale