Phenotypes Associated with This Genotype

Genotype
MGI:3804638

• Allelic Composition: Nfix^tm1.1Rmg/Nfix^tm1.1Rmg
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal brain morphology ( J:137651 )

• brain shape is elongated in the anterior to posterior direction resulting in less cerebellum exposure

increased brain weight ( J:137651 )

• brains weigh 11% to 24% more than normal and this weight increases with age

enlarged lateral ventricles ( J:137651 )

• unlike in wild-type mice, the lateral ventricles are expanded and filled with cells of unknown origin that appear at P0 and persist through at least P69

abnormal corpus callosum morphology ( J:137651 )

• more U-shaped

abnormal hippocampus morphology ( J:137651 )

• the angle of junction between the fimbria and hippocampus is more oblique than in wild-type mice

• in some brains the CA3/CA4 fields have a wavy appearance

abnormal hippocampus CA1 region morphology ( J:137651 )

• dorsal enlargement

abnormal dentate gyrus morphology ( J:137651 )

• the dentate gyrus is shorter and the angle of the arrowhead of the gyrus is larger than in wild-type mice

abnormal cerebral cortex morphology ( J:137651 )

• from P22 to P69, mice exhibit a 17% to 20% dorsal-ventral expansion of cortex and septum

growth/size/body

slow postnatal weight gain ( J:137651 )

• beginning at P8

weight loss ( J:137651 )

• at P14, mice exhibit weight loss

• however, supplementing diet with soft dough from P10 improves weight gain and survival

vision/eye

delayed eyelid opening ( J:137651 )

hearing/vestibular/ear

abnormal inner ear canal morphology ( J:137651 )

• mice exhibit a delay in the opening of the ear canal

craniofacial

craniofacial phenotype ( J:137651 )

N • mice exhibit normal tooth morphology