Phenotypes Associated with This Genotype

Genotype
MGI:3804059

• Allelic Composition: Dok1^tm1Yyam/Dok1^tm1Yyam
• Genetic Background: B6.129S4-Dok1^tm1Yyam

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:133566 )

• body weight of mice are 10% lower than controls despite being similar in length

decreased susceptibility to weight gain ( J:133566 )

• mice weigh over 20% less than controls when fed a high fat diet for 12 weeks

adipose tissue

decreased brown adipose tissue mass ( J:133566 )

• mice have significantly less BAT than controls as measured by weight

decreased fat cell size ( J:133566 )

• size of adipocytes is smaller compared to wild-type controls when both are fed a chow or a high-fat diet

• mouse embryonic fibroblasts are impaired in their ability to develop into adipocyte-like cells

decreased epididymal fat pad weight ( J:133566 )

• there are significantly less amounts of epididymal fat in these mice

decreased inguinal fat pad weight ( J:133566 )

• there are significantly less amounts of inguinal fat in these mice

decreased percent body fat/body weight ( J:133566 )

• percent body fat is reduced by more than 25% on both chow and high-fat diets

homeostasis/metabolism

decreased circulating insulin level ( J:133566 )

• insulin levels are two-thirds lower than control in mice fed a high fat diet

• plasma insulin levels are also two-thirds lower in these mice when given a bolus of glucose

decreased circulating leptin level ( J:133566 )

• mice fed a high-fat diet almost half the serum levels of leptin compared to wild-type mice

increased oxygen consumption ( J:133566 )

• mice have an increased oxygen consumption (normalized for body weight) when fed a high-fat diet

improved glucose tolerance ( J:133566 )

• mice have higher tolerance to glucose challenge after being fed a high-fat diet compared to controls

increased insulin sensitivity ( J:133566 )

• mice fed a high fat diet higher drops in blood sugar upon insulin challenge compared to wild-type mice fed the same diet

• mice have a lower score than controls on the homeostasis model assessment measure of insulin sensitivity

increased circulating adiponectin level ( J:133566 )

• mice fed a high-fat diet have higher serum levels of adiponectin