Phenotypes Associated with This Genotype

Genotype
MGI:3801600

• Allelic Composition: Srebf1^tm1Jdh/Srebf1^tm1Jdh
• Genetic Background: involves: 129S/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased survivor rate ( J:43570 )

• only 14% of expected mice survive to adulthood

lethality throughout fetal growth and development, incomplete penetrance ( J:43570 )

• despite normal appearance at E10.5, most mice die between E11.5 and E14.5

embryonic lethality during organogenesis, incomplete penetrance ( J:43570 )

• despite normal appearance at E10.5, most mice die between E11.5 and E14.5

homeostasis/metabolism

increased liver cholesterol level ( J:43570 )

• 1.5-fold

liver/biliary system

increased liver cholesterol level ( J:43570 )

• 1.5-fold