Phenotypes Associated with This Genotype

Genotype
MGI:3798788

• Allelic Composition: Dmd^mdx-5Cv/Dmd^mdx-5Cv
• Genetic Background: B6Ros.Cg-Dmd^mdx-5Cv/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:124861 )

♀N • despite defects in conduction, mice do not exhibit cardiac fibrosis or cellular hypertrophy in cardiac tissues

♀N • heart rate and ventricular repolarization, reflected on the mouse ECG by the ST interval, are similar to controls

decreased P wave amplitude ( J:124861 )

♀ • decreased amplitude and prolonged duration

prolonged P wave ( J:124861 )

♀

prolonged QRS complex duration ( J:124861 )

♀ • prolonged

abnormal myocardial fiber physiology ( J:124861 )

♀ • sodium current is decreased compared to in wild-type cardiomyocytes

muscle

increased variability of skeletal muscle fiber size ( J:164891 )

♀

centrally nucleated skeletal muscle fibers ( J:164891 )

♀

increased satellite cell number ( J:164891 )

♀ • compared with wild-type mice

abnormal muscle contractility ( J:164891 )

♀ • mice exhibit reduced muscle contractile function compared with wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Duchenne muscular dystrophy		DOID:11723	OMIM:310200	J:124861