Phenotypes Associated with This Genotype

Genotype
MGI:3798307

hm1

• Allelic Composition: Esr2^tm1Mma/Esr2^tm1Mma
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal germ cell morphology ( J:105626 )

• increased gonocytes after birth with decreased gonocyte apoptosis

reproductive system

reproductive system phenotype ( J:64426 , J:105626 )

N • contrary to previous reports, no hyperplasia of the prostate is observed (J:64426)

N • mice exhibit normal numbers of Sertoli and Leydig cells and level of testicular testosterone production (J:105626)

abnormal germ cell morphology ( J:105626 )

• increased gonocytes after birth with decreased gonocyte apoptosis

decreased corpora lutea number ( J:64426 )

♀ • despite normal follicle development, the corpus lutea are scarce or absent

reduced female fertility ( J:64426 )

♀ • despite the fertility of male mice, female mice exhibit reduced fertility to infertility

♀ • however, female genital tract morphology is normal

skeleton

skeleton phenotype ( J:123373 )

N • mice exhibit normal bone mineral content in the lumbar spine and hind leg and normal bone area and bone mineral density in the midfemur

short ulna ( J:123373 )

• slightly

decreased volumetric bone mineral density ( J:123373 )

• mice exhibit lower volumetric bone mineral density in the lumbar spine and distal femur compared with wild-type mice

abnormal bone ossification ( J:123373 )

• unloaded and loaded ulna from female mice exhibit increased bone formation measurements compared with wild-type mice

increased bone strength ( J:123373 )

• female mice exhibit increased bone stiffness and mechanical loading compared with wild-type mice

• however, male mice exhibit normal bone stiffness and mechanical loading

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:123373 )

N • unlike in previous studies, IGF-I levels are normal

abnormal response/metabolism to endogenous compounds ( J:64426 )

• when treated with gonadotropins to induce superovulation, half of mice failed to ovulate and the other half exhibited reduced yields compared to in similarly treated wild-type mice because follicles reach a preovulatory stage but fail to mature

delayed wound healing ( J:165719 )

• ovariectomized mice treated with 17beta-estradiol exhibit delayed wound healing with increased neutrophil infiltration compared with control mice

renal/urinary system

renal/urinary system phenotype ( J:64426 )

N • contrary to previous reports, no hyperplasia of the urinary bladder is observed

adipose tissue

increased total body fat amount ( J:123373 )

• in female, but not male, mice

limbs/digits/tail

short ulna ( J:123373 )

• slightly

endocrine/exocrine glands

decreased corpora lutea number ( J:64426 )

♀ • despite normal follicle development, the corpus lutea are scarce or absent

hematopoietic system

increased neutrophil cell number ( J:165719 )

• in the wounds of ovariectomized mice treated with 17beta-estradiol

immune system

increased neutrophil cell number ( J:165719 )

• in the wounds of ovariectomized mice treated with 17beta-estradiol