Analysis Tools
reproductive system
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• unlike in wild-type mice, follicles exhibit a marked deficiency in granulose cells
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• mice exhibit increased antral follicle numbers compared to in wild-type mice
• however, no cysts form and interstitial glandular cell organization is normal
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• despite the fertility of male mice, female mice exhibit reduced fertility to infertility
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homeostasis/metabolism
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• mice fail to superovulate when treated with gonadotropins because follicles reach a preovulatory stage but fail to mature unlike in similarly treated wild-type mice
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endocrine/exocrine glands
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• unlike in wild-type mice, follicles exhibit a marked deficiency in granulose cells
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• mice exhibit increased antral follicle numbers compared to in wild-type mice
• however, no cysts form and interstitial glandular cell organization is normal
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cellular
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• unlike in wild-type mice, follicles exhibit a marked deficiency in granulose cells
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