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Phenotypes Associated with This Genotype
Genotype
MGI:3798288
Allelic
Composition
Del(5D5Mit73-D5Mit351)5Jcs/+
Genetic
Background
involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

growth/size/body
• in some
• in the most severe cases the face is asymmetric
• some have misshapened palatine ridges
• Background Sensitivity: severe growth retardation averaging only 50-80% of the weight of same-sex wildtype littermates

craniofacial
• Background Sensitivity: the 'Greek warrior helmet' phenotype of domed skull, small ears, and wide set eyes is found on a >50% C57BL/6J background
• in some
• in the most severe cases the face is asymmetric and/or the jaw bones are asymmetric
• in the most severe cases the face is asymmetric
• some have misshapened palatine ridges

hearing/vestibular/ear

limbs/digits/tail

skeleton
• in some

vision/eye
• found in some

digestive/alimentary system
• some have misshapened palatine ridges

behavior/neurological
N
• Morris water maze performance normal
• froglike gait with hindlimbs splayed outward during locomotion
• although there is a trend for increased seizure incidence, statistical significance was not found, but severity of seizure is much greater than in controls with half of the seizures in heterozygotes being maximal

nervous system
• although there is a trend for increased seizure incidence, statistical significance was not found, but severity of seizure is much greater than in controls with half of the seizures in heterozygotes being maximal
• intraculminate fissure, posterior fissure, and uvular cus are lacking
• hypoplasia of the cerebral cortex results in colliculi being more exposed

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Wolf-Hirschhorn syndrome DOID:0050460 OMIM:194190
J:67077


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory