Analysis Tools
immune system
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• BCR-mediated, especially in T2 and follicular B cells
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• slight
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• slight in fetal liver transplant experiments into irradiated Jak3tm1Jni homozygotes
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• at the T2 to follicular B cell transition
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• in fetal liver transplant experiments into irradiated Jak3tm1Jni homozygotes
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• dendritic cells appear larger and rounder than wild-type cells
• dendritic cells exhibit abnormal actin organization compared with wild-type mice
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• stimulated B cells exhibit no increase in intracellular calcium unlike in wild-type cells
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• dendritic cells are less efficient than wild-type cells at inducing T cell proliferation
• dendritic cells restimulated ex-vivo with mBSA fail to release TH cytokines unlike similarly treated wild-type mice
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• dendritic cells exhibit impaired dendritic cell migration compared with wild-type cells
• dendritic cell homing to the lymph nodes is impaired compared to in wild-type mice
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• mice are protected from mBSA-induced arthritis due to defective osteoclast recruitment and T cell activation compared with similarly treated wild-type mice
• however, wild-type dendritic cells can rescue mBSA-induced inflammation but not focal osteolysis
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homeostasis/metabolism
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• stimulated B cells exhibit no increase in intracellular calcium unlike in wild-type cells
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• platelets fail to form a thrombus when blood is perfused over a collagen surface at high shear speeds unlike wild-type platelets
• in a superficial lesion, mice exhibit a decreased tendency to thrombosis compared with wild-type mice
• however, mice exhibit thrombosis upon deeper subendothelial lesion
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skeleton
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• mice are protected from mBSA-induced arthritis due to defective osteoclast recruitment and T cell activation compared with similarly treated wild-type mice
• however, wild-type dendritic cells can rescue mBSA-induced inflammation but not focal osteolysis
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hematopoietic system
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• BCR-mediated, especially in T2 and follicular B cells
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• dendritic cells exhibit impaired dendritic cell migration compared with wild-type cells
• dendritic cell homing to the lymph nodes is impaired compared to in wild-type mice
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• slight
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• slight in fetal liver transplant experiments into irradiated Jak3tm1Jni homozygotes
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• at the T2 to follicular B cell transition
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• in fetal liver transplant experiments into irradiated Jak3tm1Jni homozygotes
|
|
• dendritic cells appear larger and rounder than wild-type cells
• dendritic cells exhibit abnormal actin organization compared with wild-type mice
|
|
• stimulated B cells exhibit no increase in intracellular calcium unlike in wild-type cells
|
|
• platelets fail to form a thrombus when blood is perfused over a collagen surface at high shear speeds unlike wild-type platelets
• in a superficial lesion, mice exhibit a decreased tendency to thrombosis compared with wild-type mice
• however, mice exhibit thrombosis upon deeper subendothelial lesion
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cellular
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• BCR-mediated, especially in T2 and follicular B cells
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• dendritic cells exhibit impaired dendritic cell migration compared with wild-type cells
• dendritic cell homing to the lymph nodes is impaired compared to in wild-type mice
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