Phenotypes for Atp7a MGI:3793780 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Atp7a^Mo-br/Y
Genetic Background	involves: C57BL

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Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp7a^Mo-br mutation (1 available); any Atp7a mutation (69 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased circulating copper level ( J:5462 )

• significant reduction in serum copper (mostly found in ceruplasmin) in males is observed

abnormal noradrenaline level ( J:5462 )

• brain levels are reduced by 66% compared to wild-type males

decreased brain copper level ( J:5462 )

• copper levels in brain are reduced by 40%

increased intestine copper level ( J:5462 )

• 7-10 day-old males show an accumulation of copper in the intestinal wall

abnormal liver copper level ( J:5462 )

• 7-10 day-old males have significantly reduced (by >2-fold) liver copper levels

liver/biliary system

abnormal liver copper level ( J:5462 )

• 7-10 day-old males have significantly reduced (by >2-fold) liver copper levels

nervous system

decreased brain copper level ( J:5462 )

• copper levels in brain are reduced by 40%

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Menkes disease		DOID:1838	OMIM:309400	J:5462

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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