Analysis Tools
immune system
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• sialitis is observed in 20% of mice by 20 weeks of age which is a much lower incidence than what is observed when the mutant allele is on other backgrounds
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• gastritis occurs in all mice by 20 weeks of age but is rarely observed in when the mutant allele is on the C57BL/6 background
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• all mice have inflammation of the prostate by 20 weeks of age
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• Background Sensitivity: all mice exhibit inflammation of the ovaries on this background but while no inflammation is observed in C57BL/6 mice carrying the mutant allele
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• Background Sensitivity: mice generate autoantibodies with a reactivity that mirror the histopathology associated with this mouse strain
• Background Sensitivity: the autoantibodies from this strain consistently target stomach antigens with reactivity patterns distinctly different from the autoantibodies generated on the NOD background
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• Background Sensitivity: cornea inflammation occurs in 60% of mice of this background by 20 weeks of age but is not observed when the mutant allele is on SJL or C57BL/6 background
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• Background Sensitivity: liver inflammation is observed in 40% of mice by 20 weeks of age while no inflammation is present when the mutant allele is on the C57BL/6 background
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• Background Sensitivity: lung inflammation is observed in 50% of mice by 20 weeks of age which is a much lower incidence than observed when the mutant allele is on the NOD or SJL backgrounds
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vision/eye
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• Background Sensitivity: cornea inflammation occurs in 60% of mice of this background by 20 weeks of age but is not observed when the mutant allele is on SJL or C57BL/6 background
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• retinal degeneration resulting from autoimmune disease occurs by 20 weeks of age in 93% of mice
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endocrine/exocrine glands
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• sialitis is observed in 20% of mice by 20 weeks of age which is a much lower incidence than what is observed when the mutant allele is on other backgrounds
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• all mice have inflammation of the prostate by 20 weeks of age
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• Background Sensitivity: all mice exhibit inflammation of the ovaries on this background but while no inflammation is observed in C57BL/6 mice carrying the mutant allele
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digestive/alimentary system
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• sialitis is observed in 20% of mice by 20 weeks of age which is a much lower incidence than what is observed when the mutant allele is on other backgrounds
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• gastritis occurs in all mice by 20 weeks of age but is rarely observed in when the mutant allele is on the C57BL/6 background
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liver/biliary system
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• Background Sensitivity: liver inflammation is observed in 40% of mice by 20 weeks of age while no inflammation is present when the mutant allele is on the C57BL/6 background
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reproductive system
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• all mice have inflammation of the prostate by 20 weeks of age
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• Background Sensitivity: all mice exhibit inflammation of the ovaries on this background but while no inflammation is observed in C57BL/6 mice carrying the mutant allele
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respiratory system
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• Background Sensitivity: lung inflammation is observed in 50% of mice by 20 weeks of age which is a much lower incidence than observed when the mutant allele is on the NOD or SJL backgrounds
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| autoimmune polyendocrine syndrome type 1 | DOID:0050167 |
OMIM:240300 |
J:107432 | |
