Phenotypes Associated with This Genotype

Genotype
MGI:3771317

• Allelic Composition: Tg(Thy1-MAPT*P301L)2Vln/Tg(Thy1-MAPT*P301L)2Vln
• Genetic Background: FVB/N-Tg(Thy1-MAPT*P301L)2Vln

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:96869 )

• all homozygous mice died by 11-13 months of age

• direct cause of death could not determined

behavior/neurological

limb grasping ( J:96869 )

• less severe clasping of limbs in old (9-12 months) mice when lifted by the tail showing only partial retraction and still spreading toes

abnormal motor coordination/balance ( J:96869 )

• most homozygous mice showed moderate to severe decline in ambulation in the home cage by age 9-10 months

• only some of oldest mice revealed a motor deficit on beam walk test

paralysis ( J:96869 )

• paralysis progressed to include the forelimbs with age in all animal by age 9-10 months

hindlimb paralysis ( J:96869 )

• minor paresis of the hind limbs in some mice at 6 months

• no motor problems before age 6 months

growth/size/body

weight loss ( J:96869 )

• due to muscle and tissue wasting by 9-10 months

nervous system

nervous system phenotype ( J:96869 )

N • axonal dilations were completely absent in brain and spinal cord at any age

neurofibrillary tangles ( J:96869 )

• neurofibrillary pathology was evident in all old mice by silver impregnation and fluorescent staining with thioflavin S and X-34

• positive tauopathy was observed in brain and spinal cord neurons

tau protein deposits ( J:96869 )

• fraction of neuronal tau in aging mice was hyper phosphorylated concomitant with conformational changes and aggregation co-localizing in the same neurons

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:96869