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Phenotypes Associated with This Genotype
Genotype
MGI:3770646
cx7
Allelic
Composition		 Cd3etm1Mal/Cd3etm1Mal
Lattm1.1Mal/Lattm1.1Mal
Genetic
Background		 involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd3etm1Mal mutation (4 available); any Cd3e mutation (21 available)
Lattm1.1Mal mutation (0 available); any Lat mutation (8 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:77098 )
N
• pathological B cells of Lattm1Mal homozygotes are absent in these mice
arrested T cell differentiation ( J:77098 )
• T cells are arrested at the double negative stage
absent CD4-positive, alpha-beta T cells ( J:77098 )
• in both the thymus and spleen
absent CD8-positive, alpha-beta T cells ( J:77098 )
• in both the thymus and spleen

hematopoietic system
arrested T cell differentiation ( J:77098 )
• T cells are arrested at the double negative stage
absent CD4-positive, alpha-beta T cells ( J:77098 )
• in both the thymus and spleen
absent CD8-positive, alpha-beta T cells ( J:77098 )
• in both the thymus and spleen

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/07/2025
MGI 6.24 		The Jackson Laboratory