Analysis Tools
behavior/neurological
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• during the dark phase, mice consume 30% less food than wild-type mice
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• during the dark phase, mice consume 30% less food than wild-type mice
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• during the dark period
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• mice exhibit direct transitions from wake to REM unlike wild-type mice
• mice exhibit a decrease in the intervals between successive REM sleep periods and shorter latency to REM sleep compared to wild-type mice
• during the light period, mice exhibit shorter REM sleep and wake episodes compared to wild-type mice
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• mice show severe sleep/wake fragmentation
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narcolepsy
(
J:69620
)
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• beginning at 6 weeks of age, mice exhibit narcoleptic episodes with abrupt cessation of purposeful motor activity in which a sustained posture change is held until motion is abruptly resumed
• narcoleptic episodes occur during grooming or excited ambulation, last a few seconds to 150 seconds, and are often followed by increased feeding and drinking behaviors
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homeostasis/metabolism
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• 53% increase in the circulating leptin levels to bodyweight ratio in female but not male mice
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growth/size/body
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• at 10 to 12 weeks of age, mice exhibit increased body weight compared to wild-type mice
(J:69620)
• female but not male mice over 100 days in age have significant increases in body weight compared to littermate controls
(J:128233)
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nervous system
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• by 2 and 12 weeks of age 56% and 99%, respectively, of orexin-containing neurons are lost
(J:69620)
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| narcolepsy | DOID:8986 |
OMIM:161400 OMIM:605841 OMIM:609039 OMIM:612417 OMIM:612851 OMIM:614223 OMIM:614250 |
J:69620 | |
